Mammary NOS-type sarcoma with CD10 expression: a rare entity with features of myoepithelial differentiation.

摘要: We present an extensive immunohistochemical analysis of 7 mammary sarcomas that did not fit into any specific soft tissue sarcoma category. Histologically, they were composed spindle cells with highly pleomorphic nuclei and abundant mitoses. Our antibody panel included pan-cytokeratin (CK), basal cell type CKs (34betaE12, CK5/6, CK14, CK17) vimentin antibodies, antibodies to established (SMA, CD10, p63, S-100, maspin, calponin, GFAP, SM-myosin), novel (CD29, 14-3-3sigma) myoepithelial markers, as well CD34, desmin, h-caldesmon, steroid receptors (estrogen, progesterone, androgen), EGFR (Her-1). Whereas CKs, h-caldesmon expressed, all tumors positive for CD10 vimentin. CD29 SMA observed in 3 cases each (43%), p63 calponin 2 (29%). Other markers absent, except androgen receptors, which expressed one sarcoma. Five showed positivity EGFR. The distinction specific, histogenetically defined entities (such leiomyosarcoma, angiosarcoma, liposarcoma) from NOS-type expression is usually clear-cut because the former exhibit a characteristic histomorphology immunoprofile. Phyllodes stromal overgrowth or recurrent phyllodes lacking epithelial structures periductal can be ruled out by their frequent CD34 negativity markers. most important differential diagnosis sarcomatoid metaplastic carcinoma its treatment includes axillary lymphadenectomy. Since some carcinomas show CD29, SMA, extremely difficult requires evaluation additional such 14-3-3sigma, maspin. immunophenotype suggests these neoplasms represent variant features.