Mitochondrial synapses: intracellular communication and signal integration.

摘要: Communication is a central theme in biology. Consequently, specialized structures have evolved to permit rapid communication among cells, tissues, organs, and physiological systems, thus enhancing the overall function adaptation of organism. A prime example neuronal synapse. In brain, synaptic establishes networks with capacity integrate, process, store information, giving rise complex output signals capable orchestrating functions across At intracellular level, discoveries now reveal existence ‘mitochondrial synapses' establishing mitochondrial networks, defined chromatin-modifying gene expression genome. These raise possibility that addition their role as powerhouses neuromodulators, mitochondria behave signal-processing networks.