Imbalance of Osteoclastogenesis-Regulating Factors in Patients With Celiac Disease

摘要: Celiac disease is an autoimmune disorder characterized by atrophy of the intestine villi triggered ingestion gluten in genetically susceptible individuals. The association between celiac and low BMD has been recognized, but mechanisms disturbance are poorly understood. We show imbalance cytokines relevant to bone metabolism patients' sera direct effect these on vitro cell activity. Introduction: associated with mineral derangement BMD. investigated whether serum factors patients could affect human activity vitro. Materials Methods: studied two groups patients— one a gluten-free diet another before diet— both decreased mass. Patients were for turnover markers, their used culturing cells from healthy donors evaluate changes Results: N-terminal telopeptide procollagen type I interleukin (IL)-6 higher than normal not diet. IL-1 TNF-/ all patients. IL-12 was reduced patients, whereas IL-18 only RANKL/Osteoprotegerin (OPG) ratio increased Persistently osteoclast numbers obtained peripheral blood mono- nuclear incubation versus control In osteoblasts individuals, OPG expression lower when used. Proliferation, alkaline phosphatase, nodule mineralization osteoblast cultures containing either or Conclusions: conclude that loss might also be caused cytokine directly affecting osteoclastogenesis J Bone Miner Res 2004;19:1112-1121. Published online March 22, 2004; doi: 10.1359/JBMR.040319