Human sex hormone-binding globulin is expressed in testicular germ cells and not in sertoli cells.

摘要: The human sex hormone-binding globulin ( SHBG) gene contains at least two transcription units. A 4.3 kb SHBG unit encodes the precursor polypeptide, which is processed and secreted by hepatocytes as plasma SHBG. proximal promoter of this differs from corresponding sequence in other mammals, it also expressed Sertoli cells. In particular, its a binding site for USF factors that represses activity Although not cells, transcripts containing an alternative exon 1 are present testicular germ These products approximately 8 unit, they appear to encode isoform 4 - 5 kDa smaller than This sperm accumulates between outer acrosomal membrane membrane, released during capacitation reaction. remarkable differences expression testis, when compared force us reconsider functional significance testis relation male reproduction.