Inhibition of PDGF BB stimulated DNA synthesis in rat aortic vascular smooth muscle cells by the expression of a truncated PDGFβ receptor

作者: Paul R. Kemp , Yair Shachar-Hill , Peter L. Weissberg , James C. Metcalfe

DOI: 10.1016/0014-5793(93)81623-8

关键词:

摘要: Rat aortic vascular smooth muscle cells (VSMCs) were transfected with a vector encoding truncated human PDGFβ receptor or the full-length receptor. Cells stably expressing selected and effect of PDGF BB on DNA synthesis in these was studied. entered normally, however, failed to enter response BB. These data show that mitogenic rat can be inhibited by expression

参考文章(20)
C E Hart, R A Seifert, R Ross, D F Bowen-Pope, Synthesis, phosphorylation, and degradation of multiple forms of the platelet-derived growth factor receptor studied using a monoclonal antibody. Journal of Biological Chemistry. ,vol. 262, pp. 10780- 10785 ,(1987) , 10.1016/S0021-9258(18)61031-2
J.D. Kelly, B.A. Haldeman, F.J. Grant, M.J. Murray, R.A. Seifert, D.F. Bowen-Pope, J.A. Cooper, A. Kazlauskas, Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation Journal of Biological Chemistry. ,vol. 266, pp. 8987- 8992 ,(1991) , 10.1016/S0021-9258(18)31541-2
L Claesson-Welsh, A Eriksson, A Morén, L Severinsson, B Ek, A Ostman, C Betsholtz, C H Heldin, cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules. Molecular and Cellular Biology. ,vol. 8, pp. 3476- 3486 ,(1988) , 10.1128/MCB.8.8.3476
D Anderson, C. Koch, L Grey, C Ellis, M. Moran, T Pawson, Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors Science. ,vol. 250, pp. 979- 982 ,(1990) , 10.1126/SCIENCE.2173144
H. Ueno, H. Colbert, J. Escobedo, L. Williams, Inhibition of PDGF beta receptor signal transduction by coexpression of a truncated receptor Science. ,vol. 252, pp. 844- 848 ,(1991) , 10.1126/SCIENCE.1851331
Bo Ek, Bengt Westermark, Åke Wasteson, Carl-Henrik Heldin, Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor. Nature. ,vol. 295, pp. 419- 420 ,(1982) , 10.1038/295419A0
David R. Kaplan, Deborah K. Morrison, Gail Wong, Frank McCormick, Lewis T. Williams, PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex Cell. ,vol. 61, pp. 125- 133 ,(1990) , 10.1016/0092-8674(90)90220-9
J. Nishimura, J. S. Huang, T. F. Deuel, Platelet-derived growth factor stimulates tyrosine-specific protein kinase activity in Swiss mouse 3T3 cell membranes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 79, pp. 4303- 4307 ,(1982) , 10.1073/PNAS.79.14.4303