CYP1A1 Gene Polymorphism and Risk of Epithelial Ovarian Neoplasm

摘要: Abstract Objective. Gene–environment interactions have been the focus of a number recent studies occurrence human cancers, and an association between risk CYP1A1*3 polymorphism has noticed for several cancers. Previous suggest that estrogens are involved in etiology ovarian cancer. The cytochrome P450 1A1 (CYP1A1) gene may play role development epithelial neoplasm by detoxification polycyclic hydrocarbons other compounds concentration their metabolites. Therefore, we assessed CYP1A1 patients with Turkish populations through case-control study. Methods. Using allele-specific polymerase chain reaction (PCR)-based method, polymorphism, exon 7 gene, was analyzed 117 202 control subjects. Results. Ile/Val genotype significantly increased (OR 5.7, 95% CI 3.34–9.76). Furthermore, there were statistical differences distribution Val/Val among all 5.85, 2.40–14.25). In words, presence Val allele neoplasm. Among benign tumors, frequency genotypes found to be statistically significant ORs 6.01 4.38 (95% 2.61–13.84 1.04–18.38, respectively). serous revealed 7.2- 10.5-fold higher having carcinoma 2.22–23.40 2.16–51.19), respectively. mucinous patients, OR 5.15 1.75–15.16). However, no patient observed this group performed. borderline 5.15, only one not different 2.50 0.27–22.64). cancer 5.73, 3.04–10.76; 7.42, 2.80–19.66), suggesting carrying these at carcinoma. carcinoma, 6.5- 10-fold 7.09, 3.30–15.22; 8.77, 2.83–27.14). also 5.4 10.5 times There significance endometroid-type patients. Conclusions. Our data, although based on small subjects, variant alleles cells, directly or components, contribute initiation carcinogenesis.