In silico studies on DARC

摘要: The Duffy Antigen/Receptor for Chemokine (DARC) is a seven segment transmembrane protein. It was firstly discovered as blood group antigen and the first specific gene locus assigned to autosome in man. became more famous an erythrocyte receptor malaria parasites (Plasmodium vivax Plasmodium knowlesi), finally chemokines. DARC unorthodox chemokine (i) it binds chemokines of both CC CXC classes (ii) lacks Asp-Arg-Tyr consensus motif its second cytoplasmic loop hence cannot couple G proteins activate their signaling pathways. had also been associated cancer progression, numerous inflammatory diseases, possibly AIDS. In this review, we will summarize important biological data on DARC. Then shall focus recent development elaboration analyzes structural models We underline difficulty propose pertinent protein using comparative modeling process, other dedicated approaches Protein Blocks. chosen encompass most biochemical known date. Finally, present - docking between CXCL-8 structures. hierarchal search based separated rigid flexible docking.