Induction of Immune Responses with Clonal Dominance at High Antibody Levels

摘要: Publisher Summary This chapter discusses the induction of immune responses with clonal dominance at high antibody levels. A standard response is sum many responses. However, study expression itself or an analysis its products requires separation clones. One approach to this goal generation where one a few clones make up bulk population. The success rests on homogeneity immunogen. Bacterial cell walls, carrying regularly spaced polysaccharide structures their surface, meet demand: They are known induce predictable patterns. In rabbits, optimal conditions for eliciting dominant clonotypes antipolysaccharide specificity achieved by intravenous immunization streptococcal pneumococcal vaccines. certain inbred mouse strains, both intraperitoneal and immunizations successful in inducing large amounts restricted antibody. Inbred strains either high, intermediate, low responders group polysaccharide. under autosomal control, not linked H-2 complex as great other antigens, shows close association Ig locus that controls subclass expression.