Homogeneous antibodies: induction and value as probe for the antibody problem.

摘要: Central issues of current immunology are the molecular basis antibody specificity and origin diversity. While it is clear that a consequence amino acid sequence variable regions light heavy polypeptide chains immunoglobulin molecule, for which methodology straight forward (by determination X-ray crystallography), second problem still escapes direct attack. This question referring to two points: (1) How did diversity arise, (2) maintained? The structural data available from immunoglobulins different species, fact low vertebrates, having less than 106 lymphocytes (Du Pasquier, 1970), i.e. lower number regions, manage cope with antigenic determinants known date, appear be in support view variability vertebrates achieved mainly by evolutionary processes (Hilschmann et al., 1970; Hood Talmage, Prahl, 1971). we would like discuss is: maintained species?