Inhibition of fatty acid oxidation blocks asthma in mice (HYP2P.340)

摘要: Background: There has been a growing appreciation for the role of energy metabolic pathways in differentiation and function immune cells. Unpublished findings from our laboratory suggest that inhibiting fatty acid oxidation (FAO) modulates activation tumor-infiltrating myeloid cells, indicating potentially important FAO inflammation thus inflammatory diseases such as asthma. Objective: We sought to test hypothesis plays an asthma manifestation. Methods: Etomoxir, inhibitor rate-limiting enzyme carnithine palmitoyltransferase-1, was used ovalbumin-based murine model Results: Etomoxir treatment thirty minutes after ovalbumin challenge resulted significant reduction recruitment eosinophils macrophages into lungs without prominent effect on total number lymphocytes. also prevented ovalbumin-induced hyperresponsiveness. The protective effects etomoxir were associated with decrease Th2 cytokines ovalbumin-specific IgE production. Additionally, frequency splenic lower etomoxir-treated mice, compared control. Conclusions: Our preliminary data inhibition likely strategy block traits. As such, we are currently uncovering mechanisms by which reduces pathogenesis