Fuelling the mechanisms of asthma: Increased fatty acid oxidation in inflammatory immune cells may represent a novel therapeutic target.
A. A. Al-Khami , M. A. Ghonim , L. Del Valle , S. V. Ibba
Clinical & Experimental Allergy 47 ( 9) 1170 -1184
32
2017
MINOCYCLINE BLOCKS ALLERGEN-INDUCED EOSINOPHILIA AND PRODUCTION OF TH2 CYTOKINES AND IGE BY INTERFERING WITH THE T CELL RECEPTOR-NF-kB-GATA-3-INTERLEUKIN (IL)-4 AXIS IN A MURINE ASTHMA MODEL WITHOUT AN EFFECT ON PARP
Kusma Pyakurel , Amarjit S Naura , Hamid A Boulares , Jihang Ju
The FASEB Journal 27
2013
DNA-Dependent Protein Kinase Inhibition Blocks Asthma in Mice and Modulates Human Endothelial and CD4+T Cell Function Without Causing SCID
Mohammad Abughazleh , Kusma Pyakurel , Amarjit Naura , Hamid Boulares
The FASEB Journal 29
2015
Inhibition of fatty acid oxidation blocks asthma in mice (HYP2P.340)
Amir Al-Khami , Mohamed Ghonim , Kusma Pyakurel , Salome Ibba
Journal of Immunology 194
2015
DNA-dependent protein kinase plays a role in inflammation independent of DNA-damage repair function and its inhibition blocks allergic inflammation in mice and modulates human CD4+ T cell function without causing SCID (HYP7P.264)
Kusma Pyakurel , Amarjit Naura , Hamid Boulares , Matthew Lammi
Journal of Immunology 194
2015
Acute effect of inhaled iloprost on exercise dynamic hyperinflation in COPD patients: A randomized crossover study.
Bennett P. deBoisblanc , John B. Zamjahn , Kusma Pyakurel , Mohamed A. Ghonim
Respiratory Medicine 180 106354 -106354
2021
PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4 + T cell function
Mohamed A Ghonim , Kusma Pyakurel , Salome V Ibba , Amir A Al-Khami
Journal of Translational Medicine 13 ( 1) 225 -225
22
2015
Sulfated non-anticoagulant heparin blocks Th2-induced asthma by modulating the IL-4/signal transducer and activator of transcription 6/Janus kinase 1 pathway
Mohamed A Ghonim , Jeffrey Wang , Salome V Ibba , Hanh H Luu
Journal of Translational Medicine 16 ( 1) 1 -12
8
2018
Microparticles in systemic sclerosis: Potential pro-inflammatory mediators and pulmonary hypertension biomarkers.
Matthew R. Lammi , Lesley Ann Saketkoo , Samuel C. Okpechi , Mohamed A. Ghonim
Respirology 24 ( 7) 675 -683
6
2019
PARP is activated in human asthma and its inhibition by olaparib blocks house dust mite-induced disease in mice.
Mohamed A Ghonim , Kusma Pyakurel , Salome V Ibba , Jeffrey Wang
Clinical Science 129 ( 11) 951 -962
22
2015
Minocycline Blocks Asthma-associated Inflammation in Part by Interfering with the T Cell Receptor-Nuclear Factor κB-GATA-3-IL-4 Axis without a Prominent Effect on Poly(ADP-ribose) Polymerase
Amarjit S Naura , Hogyoung Kim , Jihang Ju , Paulo C Rodriguez
Journal of Biological Chemistry 288 ( 3) 1458 -1468
16
2013
DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4+ T-cell function without causing severe combined immunodeficiency
Mohamed A. Ghonim , Kusma Pyakurel , Jihang Ju , Paulo C. Rodriguez
The Journal of Allergy and Clinical Immunology 135 ( 2) 425 -440
19
2015
Potential of Inducible Nitric Oxide Synthase as a Therapeutic Target for Allergen-Induced Airway Hyperresponsiveness: A Critical Connection to Nitric Oxide Levels and PARP Activity
Salome’ V. Ibba , Mohamed A. Ghonim , Kusma Pyakurel , Matthew R. Lammi
Mediators of Inflammation 2016 1984703 -1984703
10
2016
Treatment with intranasal iloprost reduces disease manifestations in a murine model of previously established COPD
Matthew R. Lammi , Mohamed A. Ghonim , Kusma Pyakurel , Amarjit S Naura
American Journal of Physiology-lung Cellular and Molecular Physiology 310 ( 7)
6
2016
PARP Inhibition Blocks Asthma Manifestation in a Chronic House Dust Mite (HDM) Asthma Model and Differentially Modulates Human CD4+ T cell Function
Mohamed Ghonim , Amarjit Naura , Kusma Pyakurel , Matthew Lammi
The FASEB Journal 29 1027 -5
2015
PARP inhibition blocks chronic asthma symptoms in a house dust mite asthma model and differentially modulates human CD4+ T cell function (HYP2P. 332)
Mohamed Ghonim , Kusma Pyakurel , Salomi Ibba , Jeffery Wang
The Journal of Immunology 194 ( 1\_Supplement) 53 -13
2015
Poly (ADP-ribosyl) ation of Signal Transducer And Activator of Transcription (STAT) 6 by Poly (ADP-ribose) Polymerase (PARP)-1 Is Critical for Its Integrity And Subsequent Regulation of Th2 Cytokines during Asthma
Jeffrey Wang , Mohamed Ghonim , Salome Valentina Ibba , Kusma Pyakurel
The FASEB Journal 31 820 -7
2017
DNA‐PK Is Activated in Human Atherosclerotic Plaques And Its Partial Inhibition by Gene Heterozygosity Reduces Atherogenesis in Mouse Model of The Disease
Mohamed A Ghonim , Kusma Pyakurel , Hanh Luu , Matthew Dean
The FASEB Journal 32 570.2 -570.2
2018
MINOCYCLINE BLOCKS ASTHMA-ASSOCIATED INFLAMMATION IN PART BY INTERFERING WITH THE T CELL RECEPTOR-NF-κB-GATA-3-IL-4 AXIS WITHOUT A PROMINENT EFFECT ON PARP1
Amarjit S Naura , Hogyoung Kim , Jihang Ju , Paulo C Rodriguez
2012
THE DUAL ACTIONS OF DNA REPAIR ENZYME, PARP‐1, IN COLON INFLAMMATION AND CARCINOGENESIS
Augusto Ochoa and Hamid Boulares Abdelmetalab Fergani Tarhuni , Youssef Errami , Ali Hassan El-Bahrawy , Amir Al-Khami
The FASEB Journal 30 1268.3 -1268.3
1
2016