Acute effect of inhaled iloprost on exercise dynamic hyperinflation in COPD patients: A randomized crossover study.

摘要: Abstract Background and objective We tested whether the prostacyclin analog inhaled iloprost modulates dead space, dynamic hyperinflation (DH), systemic inflammation/oxidative stress during maximal exercise in subjects with chronic obstructive pulmonary disease (COPD) who were not selected based on hypertension (PH). Methods Twenty-four COPD patients moderate-severe obstruction (age 59 ± 7 years, FEV1 53 ± 13% predicted) participated a randomized, double-blind, placebo-controlled crossover trial. Each subject received single nebulized dose of 5.0 μg or placebo non-consecutive days followed by cardiopulmonary tests. The primary outcome was DH quantified end-expiratory lung volume/total capacity ratio (EELV/TLC) at metabolic isotime. Results Inhaled well-tolerated reduced submaximal alveolar dead-space fraction but did significantly reduce (0.70 ± 0.09 vs 0.69 ± 0.07 following iloprost, respectively, p = 0.38). Maximal time (9.1 ± 2.3 9.3 ± 2.2 min, p = 0.31) peak oxygen uptake (17.4 ± 6.3 17.9 ± 6.9 mL/kg/min, p = 0.30) different versus iloprost. Conclusions A safe space fraction; however, it efficacious modulating improving for presence PH.