Prevalence of malnutrition and obesity among cystic fibrosis patients

摘要: Background Optimal nutritional status (NS) in cystic fibrosis (CF) is associated with better lung function and increased overall survival. This study estimated the prevalence of malnutrition obesity among CF patients a tertiary center. Methods In cross-sectional 68 (33 female; 37 children/adolescents) weight, height, body composition, respiratory (% predicted forced expiratory volume 1 s; FEV1%pred) serum lipids were measured; mass index (BMI), BMI standard deviation score (BMI-SDS) percentiles calculated; Pseudomonas colonization, pancreatic insufficiency, diabetes mellitus (CFDM), liver disease (CFLD) genotype recorded; NS was classified according to 2005 Cystic Fibrosis Foundation (CFF) criteria. Frequency distributions associations between anthropometric clinical parameters (univariate/multivariate) calculated. Results Mean age (±SD) 19.81 ± 8.98 years. Regarding NS: 22.1% malnourished, 13.2% overweight/obese 29.4% had optimal NS. Pancreatic (PF), CFDM, CFLD differed significantly three groups. FEV1%pred higher correlated positively characteristics as well cholesterol negatively age. BMI-SDS PF, CFDM. Among 89.9% adequate PF 66.7% carried mutations other than F508del. No patient any traits metabolic syndrome. Conclusions Despite appropriate management only one-third present One-fourth malnourished significant percentage overweight/obese. The latter mostly carriers F508del pulmonary function. require intensive monitoring for both overweight/obesity.