Semeiology of the Gammaglobulinic Pattern of Cerebrospinal Fluid in Children

摘要: Abstract During the last 3 years, 1766 samples of matched CSF and serum from children 1 day to 17 years old were analysed. A fast, simple sensitive methodology was developed including for CSF: quantitation total protein (8 μl), albumin (10 IgG μl) agarose electrophoresis (120 μg protein). 223 (126 patients) showed a gammaglobulinic pattern (IgG index > 0.75 and/or oligoclonal banding in μ zone), indicating local synthesis within CNS. In addition, 59 an alteration blood brain barrier (albumin ratio >0.65%). The main groups diseases represented encephalitis various origins, herpes encephalitis, subacute sclerosis panencephalitis, fetal infection, meningitis, multiple sclerosis, delayed measles encephalitis. Acute could be divided into four according velocity, intensity duration pattern.