The DNA Copy Number of Human Endogenous Retrovirus-W (MSRV-Type) Is Increased in Multiple Sclerosis Patients and Is Influenced by Gender and Disease Severity

摘要: Background Multiple Sclerosis is an autoimmune disease more prevalent in women than men. Multiple Associated Retrovirus element (MSRV) a member of type-W endogenous retrovirus family (HERV-W), known to be associated MS. Most HERVs are unable replicate but MSRV expression with reverse-transcriptase activity MS would explain reported DNA copy number increase patients. A potential link between HERV-W copies on chromosome X and gender differential prevalence has been suggested. The present study addresses MSRV-type load relation the differences clinical status healthy controls. Results 178 patients (62.9% women) 124 controls (56.5% were included. env (copies/pg DNA) was analyzed by real time qPCR specific primers probe for its gene, from peripheral blood mononuclear cells (PBMCs). elevated (p = 4.15e-7). presented higher control 0.009) men also had 2.77e-6). Besides, levels men, both among 0.007) 1.24e-6). Concordantly, EDSS MSSS scores female 0.03 p 0.04, respectively). Conclusions MSRV increases PBMC particularly high scores. This may causes underlying women. association severity calls further investigations PBMCs as biomarker