Dependence of Retinogeniculate Transmission on Membrane Voltage in the Cat.

摘要: The mammalian lateral geniculate nucleus seems organized to gate or control the gain of retino-geniculate transmission, result which is then relayed visual cortex. We have performed in vivo intracellular studies retinogeniculate transmission along these retino-geniculo-cortical pathways cats by recording retinally evoked excitatory postsynaptic potential (EPSP) neurons. In cats, are into two parallel and functionally distinct channels, X Y pathways. found that nearly all cells display a fairly conventional voltage dependency for their EPSPs, because amplitudes EPSPs decrease linearly with membrane depolarization as EPSP reversal approached. Rare cells, however, show an unconventional response: over wide range potentials, increase depolarization. This does not from alterations neuronal input resistance instead due changes synaptic conductance. underlying cause this remains be determined. None less, it afford interesting means can gated, since non-retinal inputs (e.g. corticogeniculate axons) relay cell's also modulate amplitude.