摘要: The pancreatic β-cell secretes insulin in response to elevated plasma glucose. This review applies an external bioenergetic critique the central processes of glucose-stimulated secretion, including glycolytic and mitochondrial metabolism, cytosolic adenine nucleotide pool, its interaction with membrane ion channels. control mechanisms responsible for unique responsiveness cell glucose availability are discussed from metabolic standpoints. concept coupling factor facilitation secretion is critiqued, attempt made unravel basis oscillatory controlling secretion. need consider physiological constraints operating intact emphasized throughout. aim provide a coherent pathway through extensive, complex, sometimes bewildering literature, particularly those unfamiliar field.
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