Treatment of brain metastases from renal cell carcinoma with sunitinib and radiotherapy: Our experience and review of the literature

摘要: The present study reports our experience with five renal cell carcinoma (RCC) patients brain metastases treated sunitinib and radiotherapy. All had undergone radical nephrectomy. Before treatment sunitinib, radiotherapy for metastases, either by gamma-knife surgery or whole radiation, was carried out. After shrinkage of achieved in all complete response, partial response stable disease two, one two patients, respectively. Although progression occurred four the additional effective three patients. Over a 12.5-month follow up, including who maintained their best remained alive. remaining patient died progression. Despite observation several adverse events after there no intracerebral hemorrhage any patient. These findings suggest that combined radiation therapy can be safely out RCC provides favorable prognosis these cases. However, considering frequent progression, it would important to carry careful up focusing on control metastases.