Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma.

摘要: Department of Epidemiology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands. lj.schouten@epid.unimaas.nl BACKGROUND: objective this study was to report on the incidence and factors related occurrence central nervous system metastases in a cohort patients who were diagnosed with colorectal, lung, breast, or kidney carcinoma melanoma. METHODS: Using population-based Cancer Registry (MCR), created colorectal (n = 720 patients), lung 938 breast 802 renal 114 melanoma 150 patients). had live catchment area University Hospital (UHM) have been at UHM during period 1986-1995. Patients brain searched for by linking MCR Neuro-Oncology UHM. Radiology files checked as well. Follow-up lasted until December 31, 1998. RESULTS: Brain 232 (8.5%) 2724 Of these patients, 84 within 1 month after their primary diagnosis, 82 year 66 more than diagnosis. cumulative 5 years estimated 16.3% carcinoma, 9.8% 7.4% melanoma, 5.0% 1.2% carcinoma. lower age > 70 compared younger (breast carcinoma), before 1991 nonsmall cell small CONCLUSIONS: frequency highest followed There no evidence an increasing metastasis lung.