Phospholipid composition of high-density lipoproteins reflects lipolysis of triglyceride-rich lipoproteins during hyperlipidemia.

作者: NV Perova , IN Ozerova , IV Paramonova , AM Olfer'ev , NM Akhmedzhanov

DOI: 10.1023/A:1017983615183

关键词:

摘要: We studied phospholipid composition of high-density lipoproteins in patients with normo- and hypertriglyceridemia treated various hypolipidemic preparations (simvastatin fenofibrate). Both changed improved their functional activity. The differences the were probably related to lipolysis triglyceride-rich catalyzed by lipoprotein lipase and, particular, hepatic lipase.

参考文章(14)
R J Deckelbaum, S Eisenberg, Y Oschry, E Granot, I Sharon, G Bengtsson-Olivecrona, Conversion of human plasma high density lipoprotein-2 to high density lipoprotein-3. Roles of neutral lipid exchange and triglyceride lipases. Journal of Biological Chemistry. ,vol. 261, pp. 5201- 5208 ,(1986) , 10.1016/S0021-9258(19)89234-7
G Assmann, H Schriewer, G Schmitz, E O Hägele, Quantification of high-density-lipoprotein cholesterol by precipitation with phosphotungstic acid/MgCl2. Clinical Chemistry. ,vol. 29, pp. 2026- 2030 ,(1983) , 10.1093/CLINCHEM/29.12.2026
V.E. Vaskovsky, E.Y. Kostetsky, I.M. Vasendin, A universal reagent for phospholipid analysis. Journal of Chromatography A. ,vol. 114, pp. 129- 141 ,(1975) , 10.1016/S0021-9673(00)85249-8
Christine Azéma, Pedro Marques-Vidal, Anne Lespine, Gilles Simard, Hugues Chap, Bertrand Perret, Kinetic evidence for phosphatidylethanolamine and triacylglycerol as preferential substrates for hepatic lipase in HDL subfractions: modulation by changes in the particle surface, or in the lipid core. Biochimica et Biophysica Acta. ,vol. 1046, pp. 73- 80 ,(1990) , 10.1016/0005-2760(90)90096-G
Henry M. Laboda, Jane M. Glick, Michael C. Phillips, Hydrolysis of lipid monolayers and the substrate specificity of hepatic lipase. Biochimica et Biophysica Acta. ,vol. 876, pp. 233- 242 ,(1986) , 10.1016/0005-2760(86)90279-1
Alvar Svanborg, Lars Svennerholm, Ingela Myrén, M. R. Soomägi, Birgitta Claesson, Sibyl Rohman, Plasma Total Lipid, Cholesterol, Triglycerides, Phospholipids and Free Fatty Acids in a Healthy Scandinavian Population Acta Medica Scandinavica. ,vol. 169, pp. 43- 49 ,(2009) , 10.1111/J.0954-6820.1961.TB17091.X
Karim Guendouzi, Beatrice Jaspard, Ronald Barbaras, Claude Motta, Claude Vieu, Yves Marcel, Hugues Chap, Bertrand Perret, Xavier Collet, Biochemical and physical properties of remnant-HDL2 and of pre beta 1-HDL produced by hepatic lipase. Biochemistry. ,vol. 38, pp. 2762- 2768 ,(1999) , 10.1021/BI9815086