Hypothalamic–pituitary-end organ function in women with bipolar depression

摘要: Disturbance of each the three hypothalamic-pituitary-end organ systems [hypothalamic-pituitary-thyroid (HPT), -adrenal (HPA), and -gonadal (HPG)] has been reported in depressive disorders. Little is known about potential reciprocal interaction among HP-end patients with The present pilot study examined selective HPA HPG hormones a detailed time series women bipolar disorder (depressed type) before after treatment levothyroxine (L-T4), matched control subjects. Six medically stable, euthyroid, premenopausal depression, 5 age-matched controls underwent overnight blood sampling from 2100 to 0900 h for measurement adrenocorticotropic hormone (ACTH), cortisol, luteinizing (LH), estradiol every 15 min. Bipolar second procedure following 7-weeks open-label add-on L-T4. Results revealed lower baseline cortisol parameters comparison subjects, while ACTH, LH, were similar. Thyroid (TSH, free total T4) not correlated any or hormones. ACTH levels but patients. After L-T4 treatment, thyroid increased significantly depression scores declined. No significant changes observed, although small sample size may have limited results. Upon visual inspection, appeared decrease increase. These data suggest unlike previously published studies that higher depression. also axes upon pharmacological modulation HPT system, whether this change was due improvement unknown. results are preliminary, require replication larger samples.