Predictors of indoor absolute humidity and estimated effects on influenza virus survival in grade schools

摘要: Background: Low absolute humidity (AH) has been associated with increased influenza virus survival and transmissibility the onset of seasonal outbreaks. Humidification indoor environments may mitigate viral transmission be an important control strategy, particularly in schools where is common contributes to spread communities. However, variability predictors AH school environment feasibility classroom humidification levels that could decrease have not studied. Methods: Automated sensors were used measure temperature, CO2 two Minnesota grade without central during successive winters. Outdoor measurements derived from North American Land Data Assimilation System. Variability within classrooms, between classrooms same school, was assessed using concordance correlation coefficients (CCC). Predictors examined time-series Auto-Regressive Conditional Heteroskedasticity models. Classroom humidifiers when session assess increasing decreased survival, as projected previously published animal experiments. Results: varied little (CCC >0.90) but more variable 0.81 for School 1, 0.88 2) 0.81). Indoor widely winter (range 2.60 10.34 millibars [mb]) strongly changes outdoor (p < 0.001). Changes on weekdays Over 4 hours, by mb, increase sufficient 1-hour value 30% months. Conclusions: During winter, non-humidified varies substantially often are very low. results predicted over a season (which likely reflects human activity) individual days. feasible approach transmission.