Genes with Physiological Roles in Callipyge Muscle Hypertrophy
作者： Hui Yu
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摘要: Yu, Hui. Ph.D., Purdue University, December 2013. Genes with Physiological Roles in Callipyge Muscle Hypertrophy. Major Professor: Christopher A.Bidwell. sheep is an excellent model to study genes regulation muscle growth since the upregulation of DLK1 and/or RTL1 results extreme postnatal hypertrophy loin and hindquarters. are primary inducers due inheritance for callipyge phenotype. The overall aim this dissertation physiological pathways responding up / or hypertrophied muscles. Microarray analysis gene expression identified 375 that were differentially expressed semimembranosus. Twentyfive transcripts further verified by quantitative PCR two muscles (semimembranosus longissimus dorsi) one non (supraspinatus). In order identify consistently coexpressed DLK1/RTL1, current extends on these 25 4 (longissimus dorsi, semimembranosus, semitendinosus triceps brachii ) 3 nonhypertrophied (supraspinatus, infraspinatus heart). showed was significantly increased but not However, upregulated both
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