Cell cycle, cytoskeleton dynamics and beyond: the many functions of cyclins and CDK inhibitors

摘要: While targeting experiments carried out on the genes encoding many cell cycle regulators have challenged our views of control, they also suggest that redundancy might not be only explanation for observed perplexing phenotypes. Indeed, several observations hint at functions cyclins and CDK inhibitors cannot accounted by their sole role as kinase regulators. They are found involved in cellular transactions, depending or CDKs directly linked to but participating general mechanisms such transcription, DNA repair cytoskeleton dynamics. In this review we discuss roles these alternative cancer proliferation migration sometime even challenge definition markers.