作者: Luis EP Rohde , Charles H Hennekens , Paul M Ridker , None
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摘要: An elevated plasma concentration of the soluble intercellular adhesion molecule-1 (sICAM-1) is associated with increased risk for future coronary events. However, data exploring interrelations sICAM-1 known cardiovascular factors are sparse. We determined levels in 948 middle-aged men no prior history disease. age (P 4 factors, respectively (P<0.01 trend). In multivariate analysis, age, smoking status, diabetes, systolic blood pressure, positive family disease, and serum total homocysteine fibrinogen were all independently (all P=0.05). several established factors. Further studies will be needed to evaluate whether these associations reflect role as a marker preclinical atherosclerosis, such might have causal basis.