A Comparison of Fish Oil Sources for Parenteral Lipid Emulsions in a Murine Model.
作者： Gillian L. Fell , Bennet S. Cho , Amy Pan , Vania Nose , Lorenzo Anez-Bustillos
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摘要: Background: Fat emulsions are important components of parenteral nutrition (PN). Fish oil (FO) reverse cholestasis in PN-associated liver disease. There 2 FO monographs. One is “FO; rich omega-3 fatty acids” (NFO). The other, “omega-3 acids,” (PFO), enriched acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic (DHA). purpose this study to compare the effects 20% NFO PFO produced laboratory a murine model. Methods: Emulsions were compounded containing different oils: soybean (SO), NFO, two PFOs differing percentage acids as triglycerides (PFO66 PFO90). Chow-fed mice received saline, one above emulsions, or commercial (OM) intravenously (2.4 g/kg/day) for 19 days. On day 19, animals euthanized. Livers, spleens, lungs procured histologic analysis. Results: OM, SO, PFO90 well-tolerated clinically. PFO66 resulted tachypnea lethargy ~1 minut...
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