Ovulation induction, assisted conception and childhood cancer

摘要: Rapid advances have been made in the treatment of infertility over last 30 years following introduction vitro fertilisation and intracytoplasmic sperm injection. Whilst effects assisted reproductive technology (ART) on birth outcomes are well documented little is known about child health after neonatal period. Childhood cancer one area warranting further examination. The hypothesis that children may be initiated during early fetal development means events leading up to around conception important. few large-scale epidemiological studies looked at childhood incidence ART failed find any significant increased risk, some case-control reported an risk specific cancers. However, it important not interpret these findings as reason for predisposing factor, rather than procedure itself. Recent recommendations by UK's National Health Service offer intra-uterine insemination free cycle infertile couples will result increasing numbers born ART. More detailed investigations include larger plus sufficient follow-up periods information underlying causes needed since long term children, particular developing cancer, remain largely unknown.