Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture

作者: Lorraine E. Young , Kenneth Fernandes , Tom G. McEvoy , Simon C. Butterwith , Carlos G. Gutierrez

DOI: 10.1038/84769

关键词:

摘要: … c, Immuno-blotting of sheep fetal plasma using an IGF2R polyclonal antibody revealed a … mice with disrupted Igf2r expression 4,5,6 , our observations indicate a causative role for IGF2R …

参考文章(15)
J. H. Butler, P. D. Gluckman, Circulating insulin-like growth factor-binding proteins in fetal, neonatal and adult sheep. Journal of Endocrinology. ,vol. 109, pp. 333- 338 ,(1986) , 10.1677/JOE.0.1090333
Zhao-Qi Wang, Marion R. Fung, Denise P. Barlow, Erwin F. Wagner, Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr gene. Nature. ,vol. 372, pp. 464- 467 ,(1994) , 10.1038/372464A0
M M Lau, C E Stewart, Z Liu, H Bhatt, P Rotwein, C L Stewart, Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality. Genes & Development. ,vol. 8, pp. 2953- 2963 ,(1994) , 10.1101/GAD.8.24.2953
Philip A. Leighton, Robert S. Ingram, Jonathan Eggenschwiler, Argiris Efstratiadis, Shirley M. Tilghman, Disruption of imprinting caused by deletion of the H19 gene region in mice Nature. ,vol. 375, pp. 34- 39 ,(1995) , 10.1038/375034A0
KD Sinclair, TG McEvoy, C Carolan, EK Maxfield, CA Maltin, LE Young, I Wilmut, JJ Robinson, PJ Broadbent, Conceptus growth and development following in vitro culture of ovine embryos in media supplemented with bovine sera Theriogenology. ,vol. 49, pp. 218- 218 ,(1998) , 10.1016/S0093-691X(98)90571-4
En Li, Timothy H. Bestor, Rudolf Jaenisch, Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell. ,vol. 69, pp. 915- 926 ,(1992) , 10.1016/0092-8674(92)90611-F
Thomas Ludwig, Jonathan Eggenschwiler, Peter Fisher, A.Joseph D'Ercole, Marsha L. Davenport, Argiris Efstratiadis, Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds. Developmental Biology. ,vol. 177, pp. 517- 535 ,(1996) , 10.1006/DBIO.1996.0182
JOHN I. JONES, DAVID R. CLEMMONS, Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions* Endocrine Reviews. ,vol. 16, pp. 3- 34 ,(1995) , 10.1210/EDRV-16-1-3
Michael Landthaler, John Welsh, Barbara Jung, Hiroaki Kobayashi, Robert S. Kerbel, Wilhelm Stolz, Michael McClelland, Thomas Vogt, Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas. Clinical Cancer Research. ,vol. 4, pp. 791- 797 ,(1998)