Embryo culture and epigenetics
作者： Brenna A. Market Velker , Michelle M. Denomme , Mellissa R. W. Mann
DOI: 10.1007/978-1-61779-971-6_23
关键词:
摘要: During preimplantation development, major epigenetic reprogramming occurs, erasing gametic modifications, and establishing embryonic modifications. Given the plasticity of these they are susceptible to disruption by assisted reproductive technologies, including embryo culture. The current state evidence is presented for effects culture on global DNA methylation histone retroviral silencing, X-inactivation, genomic imprinting. Several salient points emerge from literature; that in absence other procedures can lead perturbations; all media suboptimal; response vitro stochastic. We propose embryos adapt suboptimal environment generated culture, adaptations, "quiet" may be least epigenetically compromised
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