First drugs found to inhibit elusive cancer target.

作者: Melinda Wenner Moyer

DOI: 10.1038/NM1111-1325

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参考文章(7)
Mark A. Dawson, Rab K. Prinjha, Antje Dittmann, George Giotopoulos, Marcus Bantscheff, Wai-In Chan, Samuel C. Robson, Chun-wa Chung, Carsten Hopf, Mikhail M. Savitski, Carola Huthmacher, Emma Gudgin, Dave Lugo, Soren Beinke, Trevor D. Chapman, Emma J. Roberts, Peter E. Soden, Kurt R. Auger, Olivier Mirguet, Konstanze Doehner, Ruud Delwel, Alan K. Burnett, Phillip Jeffrey, Gerard Drewes, Kevin Lee, Brian J. P. Huntly, Tony Kouzarides, Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia Nature. ,vol. 478, pp. 529- 533 ,(2011) , 10.1038/NATURE10509
J. A. Mertz, A. R. Conery, B. M. Bryant, P. Sandy, S. Balasubramanian, D. A. Mele, L. Bergeron, R. J. Sims, Targeting MYC dependence in cancer by inhibiting BET bromodomains Proceedings of the National Academy of Sciences of the United States of America. ,vol. 108, pp. 16669- 16674 ,(2011) , 10.1073/PNAS.1108190108
Ildiko Felletar, Martin Philpott, Shonagh Munro, Michael R. McKeown, Yuchuan Wang, Amanda L. Christie, Nathan West, Michael J. Cameron, Brian Schwartz, Tom D. Heightman, Nicholas La Thangue, Christopher A. French, Olaf Wiest, Andrew L. Kung, Stefan Knapp, James E. Bradner, Panagis Filippakopoulos, Jun Qi, Sarah Picaud, Yao Shen, William B. Smith, Oleg Fedorov, Elizabeth M. Morse, Tracey Keates, Tyler T. Hickman, Selective inhibition of BET bromodomains Nature. ,vol. 468, pp. 1067- 1073 ,(2010) , 10.1038/NATURE09504
D. A. Bisgrove, T. Mahmoudi, P. Henklein, E. Verdin, Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 13690- 13695 ,(2007) , 10.1073/PNAS.0705053104
Jake E. Delmore, Ghayas C. Issa, Madeleine E. Lemieux, Peter B. Rahl, Junwei Shi, Hannah M. Jacobs, Efstathios Kastritis, Timothy Gilpatrick, Ronald M. Paranal, Jun Qi, Marta Chesi, Anna C. Schinzel, Michael R. McKeown, Timothy P. Heffernan, Christopher R. Vakoc, P. Leif Bergsagel, Irene M. Ghobrial, Paul G. Richardson, Richard A. Young, William C. Hahn, Kenneth C. Anderson, Andrew L. Kung, James E. Bradner, Constantine S. Mitsiades, BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc Cell. ,vol. 146, pp. 904- 917 ,(2011) , 10.1016/J.CELL.2011.08.017
Johannes Zuber, Junwei Shi, Eric Wang, Amy R. Rappaport, Harald Herrmann, Edward A. Sison, Daniel Magoon, Jun Qi, Katharina Blatt, Mark Wunderlich, Meredith J. Taylor, Christopher Johns, Agustin Chicas, James C. Mulloy, Scott C. Kogan, Patrick Brown, Peter Valent, James E. Bradner, Scott W. Lowe, Christopher R. Vakoc, RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia Nature. ,vol. 478, pp. 524- 528 ,(2011) , 10.1038/NATURE10334
Richard A. Young, Peter B. Rahl, Charles Y. Lin, Amy C. Seila, Ryan A. Flynn, Scott McCuine, Christopher B. Burge, Phillip A. Sharp, c-Myc Regulates Transcriptional Pause Release Cell. ,vol. 141, pp. 432- 445 ,(2010) , 10.1016/J.CELL.2010.03.030