In Vivo Validation of Electrocardiographic Imaging.

摘要: Abstract Objectives The purpose of this study was to evaluate the accuracy noninvasive reconstructions epicardial potentials, electrograms, activation and recovery isochrones, beat origins by simultaneously performing electrocardiographic imaging (ECGI) invasive electrography in intact animals. Background Noninvasive electrical potentials at epicardium, known as ECGI, is increasingly applied patients assess normal abnormal cardiac activity. Methods Body-surface were recorded anesthetized dogs. Computed tomography scanning provided a torso-heart geometry that used reconstruct from body-surface potentials. Results Electrogram attained moderate compared with recordings (median correlation coefficient: 0.71), but considerable variation (interquartile range: 0.36 0.86). This could be explained spatial mismatch (overall resolution 20 mm) most apparent regions electrographic transition. More accurate derivation times (Pearson R: 0.82), (R: 0.73), origin paced beats error: 10 mm; interquartile 7 17 achieved spatiotemporal approach incorporates characteristics respective electrogram neighboring electrograms. Reconstruction repeated single-site pacing showed stable localization origin. Cardiac motion, currently ignored correlates negatively reconstruction accuracy. Conclusions ECGI shows decent median accuracy, variability can sizable. At present, therefore, clinical interpretations should not made on basis single electrograms only. Incorporating local allows for patterns, 10-mm precision. Even more reliable are expected when influences motion accounted ECGI.