Imaging disulfide dinitroxides at 250 MHz to monitor thiol redox status.
作者： Hanan Elajaili , Joshua R. Biller , Gerald M. Rosen , Joseph P.Y. Kao , Mark Tseytlin
DOI: 10.1016/J.JMR.2015.08.027
关键词:
摘要: Measurement of thiol-disulfide redox status is crucial for characterization tumor physiology. The electron paramagnetic resonance (EPR) spectra disulfide-linked dinitroxides are readily distinguished from those the corresponding monoradicals that formed by cleavage disulfide linkage free thiols. EPR can thus be used to monitor rate and thiol status. (1)H,(14)N- (2)H,(15)N-disulfide resulting glutathione have been characterized at 250 MHz, 1.04 GHz, 9 GHz imaged rapid-scan MHz.
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