Dehydroretronecine-induced rhabdomyosarcomas in rats.

摘要: Summary Two groups of rats were given s.c. injections either monocrotaline or its major detectable metabolite, dehydroretronecine, biweekly for 1 year. Tissues obtained from partial hepatectomies performed at 4 months on a portion these animals showed that both compounds caused decided inhibition mitotic division in regenerating liver. Rhabdomyosarcomas developed the site dehydroretronecine injection 51.6% and 3.3% monocrotaline-treated rats. Metastatic lesions recorded 8.3% animals. In addition to above, 10% other tumors included myelogenous leukemias, hepatocellular carcinomas, pulmonary adenomas. These data indicate metabolite are capable causing neoplastic transformations tissues experimental