Alkaloids Derived From Ornithine: Pyrrolizidine Alkaloids 13

作者: Helmut Wiedenfeld

DOI:

关键词:

摘要: Pyrrolizidine alkaloids (PAs) occur in about 5% of all flowering plants. They are esters a basic moiety (“Necine”) and esterifying acids (“necic acids”). Up to now, 500 different PAs described. can be hazardous man domestic animal. show cancerogenic, mutagenic, teratogenic, fetotoxic properties. Many intoxications by The level the toxicity each single PA is dependent from its concrete chemical structure. This chapter gives an overview chemistry, biosynthesis, PAs.

参考文章(118)
Liu Wc, Rao Kv, Kugelman M, Axelrod M, McBride Tj, Indicine-N-oxide: the antitumor principle of Heliotropium indicum. Lloydia. ,vol. 39, pp. 125- 128 ,(1976)
D. E. Goeger, P. R. Cheeke, J. A. Schmitz, D. R. Buhler, Toxicity of tansy ragwort (Senecio jacobaea) to goats. American Journal of Veterinary Research. ,vol. 43, pp. 252- 254 ,(1982)
E. Roeder, H. Wiedenfeld, Pyrrolizidine alkaloids in medicinal plants of Mongolia, Nepal and Tibet Die Pharmazie. ,vol. 64, pp. 699- 716 ,(2009)
D. J. Robins, The pyrrolizidine alkaloids. Progress in the chemistry of organic natural products. Progrès dans la chimie des substances organiques naturelles. ,vol. 41, pp. 115- 202 ,(1982) , 10.1007/978-3-7091-8656-5_4
P. A. Mohamed, R. R. King, J. O. Dickinson, M. P. Cooke, Milk transfer of pyrrolizidine alkoloids in cattle. Javma-journal of The American Veterinary Medical Association. ,vol. 169, pp. 1192- 1196 ,(1976)
D. G. Steyn, Poisoning of human beings by weeds contained in cereals (bread poisoning). The Onderstepoort journal of veterinary science and animal industry. ,vol. 1, pp. 219- 266 ,(1933)
Laurine A. Carstens, Ih-Chang Hsu, James R. Allen, Dehydroretronecine-induced rhabdomyosarcomas in rats. Cancer Research. ,vol. 35, pp. 997- 1002 ,(1975)
Roger A Coulombe, Pyrrolizidine alkaloids in foods. Advances in food and nutrition research. ,vol. 45, pp. 61- 99 ,(2003) , 10.1016/S1043-4526(03)45003-1