Plasma calcidiol, calcitriol, and parathyroid hormone and risk of new onset heart failure in a population-based cohort study

摘要: Background Heart failure (HF) is a major problem in the Western world, with increasing prevalence and incidence. Because HF cannot be cured, prevention of utter importance. Calcidiol, calcitriol, parathyroid hormone (PTH) have been identified as risk factors for cardiovascular disease. However, their association new onset remains to established. We investigated whether calcidiol, PTH could used identify those subjects at HF, if they had additive predictive value over established predictors like N-terminal-pro Brain-type natriuretic peptide highly sensitive Troponin-T. Methods results We examined 7470 HF-free participants Prevention Renal Vascular End-stage Disease, community-based cohort study Groningen, Netherlands (latitude 53°N, mean age: 49 years, 48% male). During follow-up time 12.6 years (interquartile range: 12.3–12.9), 281 (4%) developed HF: 181 (66%) reduced 94 (34%) preserved ejection fraction (HFrEF [left ventricular fraction ≤ 40%], HFpEF fraction ≥ 50%], respectively). Mean (±SD) calcidiol was 58 (±24) nmol/L, calcitriol 145 (±48) pmol/L, median range) 3.7 (3.0–4.6) pmol/L. Calcidiol levels were univariately associated [hazard ratio (HR) 0.82 (95% CI 0.69–0.96)], but not [HR 0.85 0.71–1.03)]. kept after adjustment age, sex, day blood withdrawal (HR 1.26 [95% 1.04–1.53]). our full model this lost 1.10 0.92–1.32)]. differentiate between HFrEF or HFpEF. Conclusions After confounding factors, single measurement plasma developing HF. Screening these markers advocated.