Cellular and molecular basis of barrier function in oral epithelium.

摘要: The use of the oral mucosa for drug delivery and erroneous belief that it is a nonkeratinized tissue have given rise to suggestion permeable tissue. Such an assumption not supported by studies which indicate permeability differs significantly in different regions, depending on pattern epithelial differentiation. Keratinized regions such as hard palate gingiva less than like buccal floor mouth. Nevertheless, all are more skin. Associated with these differences type amount intercellular lipid; areas keratinized contain predominantly neutral lipids (ceramides) apparently derived from lamellate membrane-coating granules. In areas, consist yet uncharacterized glycosyl ceramides appear be granules differ morphologically those present