Buccal Delivery of Biopharmaceuticals: Vaccines and Allergens

摘要: Oral delivery of most biopharmaceuticals is limited due to their acidic and enzymatic degradation in the gastrointestinal tract. Furthermore, high molecular weight these drugs often results poor absorption through membranes into systemic circulation when administered orally. Among new strategies for an improved therapy with via different routes administration such as various mucosas (oral, nasal, vaginal, rectal, etc.) besides parenteral delivery. In this chapter, we will focus on oral mucosa alternative route biopharmaceuticals, specifically vaccines allergens, almost all data reported mucosal are related recombinant allergens.