Genetic and Environmental Contributions to the Association Between Quantitative Ultrasound and Bone Mineral Density Measurements: A Twin Study

摘要: This study was designed to assess the relative contributions of genetic and environmental factors variation covariation quantitative ultrasound (QUS) measurements their relationships bone mineral density (BMD). Forty-nine monozygotic (MZ) 44 dizygotic (DZ) female twins between 20 83 years age (53 ± 13 years, mean SD) were studied. Digital (phalangeal) QUS (speed sound [SOS]) calcaneal (broadband attenuation [BUA] velocity [VOS]) measured using a DBM Sonic 1200 densitometer CUBA densitometer, respectively. Femoral neck (FN), lumbar spine (LS), total body (TB) BMD dual-energy X-ray absorptiometry. Familial resemblance hence heritability (proportion variance trait attributable factors) assessed by analysis variance, univariate, multivariate model-fitting analyses. In both parameters, MZ more alike than DZ pairs. Estimates for age- weight-adjusted BUA, VOS, SOS 0.74, 0.55, 0.82, Corresponding indices LS, FN, TB 0.79, 0.77, cross-sectional analysis, BUA SOS, but not independently associated with measurements. However, based on intrapair differences suggested that only related BMD. Bivariate indicated correlations ranged 0.43 0.51 (p < 0.001), whereas 0.20 0.28 0.01). While within significant, factor indicates common genes affect at different sites. Also, individual appear be influenced some sets rather factors. Significant found 0.50 0.65 0.001). These data suggest are highly heritable traits. it appears there is set influencing measurements, specific yet identified have greater effects shared in each trait.