Cytosine arabinoside substitution decreases transcription factor-DNA binding element complex formation.
作者： Frederick L. Kiechle , Ximbo Zhang
DOI: 10.1043/1543-2165(2004)128<1364:CASDTF>2.0.CO;2
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摘要: Abstract Context.—The pyrimidine nucleoside analog, cytosine arabinoside (Ara-C), is an effective therapeutic agent for acute leukemia. The phosphorylated triphosphate, competes with deoxycytosine triphosphate as a substrate incorporation into DNA. Once incorporated DNA, it inhibits DNA polymerase and topoisomerase I modifies the tertiary structure of Objective.—To determine if substitution Ara-C in double-stranded oligonucleotides that contain 4 specific transcription factor binding sites (TATA, GATA, C/EBP, AP-2α) alters to their respective elements. Design.—Transcription factors were obtained from nuclear extracts human promyelocytic leukemia HL-60 cells. [32P]-end-labeled contained 1 or 2 without used assess by electrophoret...
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