Drug Resistance Against Tyrosine Kinase Inhibitor in Gastrointestinal Malignancies

摘要: Gastrointestinal cancers are heterogeneous and complex among the most common human cancers. In spite of this complexity, certain types genetic alterations linked to specific pathological lesions. Genomic transcriptomic analyses have disclosed molecular subtypes that characterized by aberrations expression signatures. Identification better markers assist detection prognostic evaluation cancer is therefore required. Tyrosine kinases enzymes responsible for activation many proteins signal transduction cascades. Inhibitors tyrosine (TKIs) been effectively used clinical treatment cancer. Chronic exposure gradually increasing concentrations TKI over a period time, cells activating modified signaling pathway can replace lack in target therapy, leading development drug resistance. recent years, researchers specified different subsets kinase inhibitors’ potential resistance mechanisms various gastric This chapter intends provide an overview recently identified acquired kinase-targeted therapy gastrointestinal malignancies.