Phase II Trial of Cetuximab in Patients With Refractory Colorectal Cancer That Expresses the Epidermal Growth Factor Receptor

作者: Leonard B. Saltz , Neal J. Meropol , Patrick J. Loehrer , Michael N. Needle , Justin Kopit

DOI: 10.1200/JCO.2004.10.182

关键词:

摘要: Purpose To evaluate the antitumor activity and toxicity of single-agent cetuximab in patients with chemotherapy-refractory colorectal cancer whose tumors express the epidermal growth …

参考文章(32)
Tony DeBlasio, Mark Rubin, Zhen Fan, Andrew Koff, Tim Soos, John Mendelsohn, Xipu Wu, Involvement of p27KIP1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody. Oncogene. ,vol. 12, pp. 1397- 1403 ,(1996)
G. H. Sato, J. Mendelsohn, J. Polikoff, J. D. Sato, A. D. Le, T. Kawamoto, Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors. Molecular biology & medicine. ,vol. 1, pp. 511- 529 ,(1983)
Zhen Fan, Hideo Masui, John Mendelsohn, Jose Baselga, Antitumor Effect of Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies plus cis-Diamminedichloroplatinum on Well Established A431 Cell Xenografts Cancer Research. ,vol. 53, pp. 4637- 4642 ,(1993)
Gordon Sato, Bonnie Wolf, Tomoyuki Kawamoto, John Mendelsohn, J. Denry Sato, Hideo Masui, Growth Inhibition of Human Tumor Cells in Athymic Mice by Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies Cancer Research. ,vol. 44, pp. 1002- 1007 ,(1984)
G Carpenter, S Cohen, Epidermal growth factor. Journal of Biological Chemistry. ,vol. 265, pp. 7709- 7712 ,(1972) , 10.1016/S0021-9258(19)38983-5
Tony DeBlasio, Zhen Fan, Yang Lu, Ding Peng, John Mendelsohn, Howard Scher, Howard Scher, Anti-epidermal growth factor receptor monoclonal antibody 225 up-regulates p27KIP1 and induces G1 arrest in prostatic cancer cell line DU145. Cancer Research. ,vol. 56, pp. 3666- 3669 ,(1996)
Pilar Garin Chesa, Francisco X. Real, Lloyd J. Old, John Mendelsohn, Myron R. Melamed, Wolfgang J. Rettig, Expression of Epidermal Growth Factor Receptor in Human Cultured Cells and Tissues: Relationship to Cell Lineage and Stage of Differentiation Cancer Research. ,vol. 46, pp. 4726- 4731 ,(1986)