Expression of Epidermal Growth Factor Receptor in Human Cultured Cells and Tissues: Relationship to Cell Lineage and Stage of Differentiation

摘要: Mouse monoclonal antibodies have been used to study the distribution of epidermal growth factor receptor in human cultured cells and tissues. As expected, most epithelial expressed (EGFr), whereas hematopoietic origin were EGFr-. However, EGFr was found be differentially on neuroectodermal origin. Normal melanocytes a proportion melanomas are EGFr-, distinct subset other melanomas, astrocytomas, neuroblastomas is EGFr+. Expression closely related expression phenotypic traits differentiation. Less differentiated an epithelioid morphology nonpigmented, Ia+, EGFr+; contrast, more dendritic pigmented, Ia-, In melanoma cell panel used, did not correlate with rate proliferation. tissues also showed lack correlation proliferative state cells. Our findings indicate that lineage specific stages cellular differentiation, rather than only The data suggest content may elevated large number tumor lines.