Anti-Growth Factor Receptor Antibodies as Therapy for Cancer
作者： Raymond Taetle
DOI: 10.1007/978-1-4615-3492-1_18
关键词:
摘要: The idea of attacking cancer cells at the cell surface was revived in past decade by availability monospecific heteroantisera. Phase I trials using monoclonal antibodies to most tumor antigens have shown little anti-tumor activity (Reviewed 1,2). reasons for these failures are complex, but include heterogeneity antigen expression; antibodyinduced modulation from surface; formation human anti-mouse antibodies; and uncertain efficacy host response (1,2). Immunoconjugates employing as carriers toxins, drugs, or radioisotopes chimeric human-mouse remain under investigation
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