Epidermal growth factor receptors in human breast cancer.

摘要: Epidermal Growth Factor (EGF) is a small (6045 Dalton) protein that stimulates cell proliferation in both culture systems and intact animals. EGF was first isolated from the submaxillary gland of mouse by Cohen 1962 [1]. Extracts when injected into newborn animals induced precocious eyelid opening incisor eruption. At time, involved research on Nerve but realized potential importance substance with such profound biological effects. The response to injection extracts due stimulation epidermal growth keratinization. factor responsible for these effects named Factor. molecule contains 53 amino acid residues [2] has disulphide bonds between cysteine 5 20, 14 31, 33 42, producing three loops secondary structure [3]. Mouse produced much larger precursor molecular 130,000 Daltons [4]. In mid 1970s, detected [5] human urine [6]. 1975 Gregory demonstrated equivalent urogastrone, hormone capable inhibiting gastric secretion. urogastrone (Uro-EGF) share 70% homology are antigenically distinct as shown radioimmunoassay [7]. They are, however, interchangeable radioligand assays stimulatory experiments.