The Cholesterol Side‐Chain Cleavage Complex in Human Brain White Matter
作者： C. Goascogne , M. Gouézou , P. Robel , G. Defaye , E. Chambaz
DOI: 10.1111/J.1365-2826.1989.TB00095.X
关键词:
摘要: Specific antibodies obtained in rabbits after injection of bovine cholesterol side-chain cleavage enzymes cytochrome P-~~OSCC, adrenodoxin and adrenodoxin-reductase were used for immunohistochemical studies human brain. The three co-localized the white matter cerebellum. This observation strongly suggests existence steroidogenic activity oligodendrocytes, as previously reported rat, that concept 'neurosteroids' can be applied to A5-38-hydroxysteroid metabolites accumulate
sci-hub.se 参考文章(10)
P. Robel, E. Bourreau, C. Corpéchot, D.C. Dang, F. Halberg, C. Clarke, M. Haug, M.L. Schlegel, M. Synguelakis, C. Vourch, E.E. Baulieu, Neuro-steroids: 3β-hydroxy-δ5-derivatives in rat and monkey brain Journal of Steroid Biochemistry. ,vol. 27, pp. 649- 655 ,(1987) , 10.1016/0022-4731(87)90133-6
SEYMOUR LIEBERMAN, NORMA J. GREENFIELD, ADELE WOLFSON, A Heuristic Proposal for Understanding Steroidogenic Processes Endocrine Reviews. ,vol. 5, pp. 128- 148 ,(1984) , 10.1210/EDRV-5-1-128
Z. Y. Hu, E. Bourreau, I. Jung-Testas, P. Robel, E. E. Baulieu, Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 84, pp. 8215- 8219 ,(1987) , 10.1073/PNAS.84.23.8215
C Le Goascogne, P Robel, M Gouezou, N Sananes, E. Baulieu, M Waterman, Neurosteroids: cytochrome P-450scc in rat brain Science. ,vol. 237, pp. 1212- 1215 ,(1987) , 10.1126/SCIENCE.3306919
A. Lanthier, V.V. Patwardhan, Sex steroids and 5-en-3β-hydroxysteroids in specific regions of the human brain and cranial nerves Journal of Steroid Biochemistry. ,vol. 25, pp. 445- 449 ,(1986) , 10.1016/0022-4731(86)90259-1
Colette Corpéchot, Monique Synguelakis, Saliha Talha, Magnus Axelson, Jan Sjövall, Reijo Vihko, Etienne-Emile Baulieu, Paul Robel, Pregnenolone and its sulfate ester in the rat brain Brain Research. ,vol. 270, pp. 119- 125 ,(1983) , 10.1016/0006-8993(83)90797-7
Maria Dorota Majewska, Rochelle D. Schwartz, Pregnenolone-sulfate: an endogenous antagonist of the γ-aminobutyric acid receptor complex in brain? Brain Research. ,vol. 404, pp. 355- 360 ,(1987) , 10.1016/0006-8993(87)91394-1
Claude Lacroix, Jean Fiet, Jean-Pierre Benais, Bernard Gueux, Rémi Bonete, Jean-Marie Villette, Bernard Gourmel, Claude Dreux, Simultaneous radioimmunoassay of progesterone, androst-4-enedione, pregnenolone, dehydroepiandrosterone and 17-hydroxyprogesterone in specific regions of human brain Journal of Steroid Biochemistry. ,vol. 28, pp. 317- 325 ,(1987) , 10.1016/0022-4731(87)91025-9
C. Corpechot, P. Robel, M. Axelson, J. Sjovall, E. E. Baulieu, Characterization and measurement of dehydroepiandrosterone sulfate in rat brain. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 78, pp. 4704- 4707 ,(1981) , 10.1073/PNAS.78.8.4704
R. J. RODGERS, M. R. WATERMAN, E. R. SIMPSON, Cytochromes P-450scc, P-45017α, Adrenodoxin, and Reduced Nicotinamide Adenine Dinucleotide Phosphate-Cytochrome P-450 Reductase in Bovine Follicles and Corpora Lutea. Changes in Specific Contents during the Ovarian Cycle* Endocrinology. ,vol. 118, pp. 1366- 1374 ,(1986) , 10.1210/ENDO-118-4-1366