Putative mechanism of the itch-scratch circle: repeated scratching decreases the cutaneous level of prostaglandin D2, a mediator that inhibits itching.
作者： Masanori Sugimoto , Iwao Arai , Nobuko Futaki , Yusuke Honma , Takanobu Sakurai
DOI: 10.1016/J.PLEFA.2006.11.007
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摘要: Abstract In atopic dermatitis, scratching of the skin as a reaction to itching causes injury skin, which, in turn, further increases resulting establishment so-called itch–scratch circle. We have shown that prostaglandin (PG) D 2 plays an inhibitory role against pruritus mice with atopic-like dermatitis; therefore, we examined relationship between and cutaneous PGD level using artificial model wire brush. Mechanical induced temporary increase PGs levels (PGE , 6-ketoPGF 1 α PGF ). The ability production decreased at 48h after repeated scratch, compared normal not so single scratch. Immunohistochemical analysis Western blotting revealed decrease cyclooxygenase-1 (COX-1) hematopoietic synthase mechanically scratched skin. reduced for following mechanical could be caused by this expression COX-1 synthase. results suggest decreases produce which is endogenous mediator inhibits pruritus,
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Yoshihiro Urade, Osamu Hayaishi, Prostaglandin D synthase: structure and function. Vitamins and Hormones Series. ,vol. 58, pp. 89- 120 ,(2000) , 10.1016/S0083-6729(00)58022-4
A. Ikoma, M. Fartasch, G. Heyer, Y. Miyachi, H. Handwerker, M. Schmelz, Painful stimuli evoke itch in patients with chronic pruritus Central sensitization for itch Neurology. ,vol. 62, pp. 212- 217 ,(2004) , 10.1212/WNL.62.2.212
R. Ueno, S. Narumiya, T. Ogorochi, T. Nakayama, Y. Ishikawa, O. Hayaishi, Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide Proceedings of the National Academy of Sciences of the United States of America. ,vol. 79, pp. 6093- 6097 ,(1982) , 10.1073/PNAS.79.19.6093
Peter A. Klein, Richard A. F. Clark, An evidence-based review of the efficacy of antihistamines in relieving pruritus in atopic dermatitis. Archives of Dermatology. ,vol. 135, pp. 1522- 1525 ,(1999) , 10.1001/ARCHDERM.135.12.1522
H. Giles, P. Leff, The biology and pharmacology of PGD2. Prostaglandins. ,vol. 35, pp. 277- 300 ,(1988) , 10.1016/0090-6980(88)90093-7
Mayumi. Ujihara, Yuji. Horiguchi, Kouichi. Ikai, Yoshihiro. Urade, Characterization and distribution of prostaglandin D synthetase in rat skin. Journal of Investigative Dermatology. ,vol. 90, pp. 448- 451 ,(1988) , 10.1111/1523-1747.EP12460883
Masanori Sugimoto, Iwao Arai, Nobuko Futaki, Yuki Hashimoto, Takanobu Sakurai, Yusuke Honma, Shiro Nakaike, Time course changes of scratching counts, dermatitis symptoms, and levels of cutaneous prostaglandins in NC/Nga mice Experimental Dermatology. ,vol. 15, pp. 875- 882 ,(2006) , 10.1111/J.1600-0625.2006.00480.X
Yusuke Honma, Iwao Arai, Yuki Hashimoto, Nobuko Futaki, Masanori Sugimoto, Makoto Tanaka, Shiro Nakaike, Prostaglandin D2 and prostaglandin E2 accelerate the recovery of cutaneous barrier disruption induced by mechanical scratching in mice. European Journal of Pharmacology. ,vol. 518, pp. 56- 62 ,(2005) , 10.1016/J.EJPHAR.2005.06.006
Naohiro Watanabe, Yoshiaki Tomimori, Kayo Saito, Kenju Miura, Adumi Wada, Masaoki Tsudzuki, Yoshiaki Fukuda, Chymase inhibitor improves dermatitis in NC/Nga mice. International Archives of Allergy and Immunology. ,vol. 128, pp. 229- 234 ,(2002) , 10.1159/000064256
Carl-Fredrik Wahlgren, Itch and Atopic Dermatitis: An Overview The Journal of Dermatology. ,vol. 26, pp. 770- 779 ,(1999) , 10.1111/J.1346-8138.1999.TB02090.X