Cytotoxicity of gamma-ray in rat immature hippocampal neurons
作者： Miyoung Yang , Myoung-Sub Song , Sung-Ho Kim , Jong-Choon Kim , Joong-Sun Kim
DOI: 10.4142/JVS.2011.12.3.203
关键词:
摘要: This in vitro study evaluated the detrimental effect of acute gamma (γ)-irradiation on rat immature hippocampal neurons. Rat neurons (0.5 day vitro) were irradiated with 0~4 Gy γ-rays. Cytotoxicity was analyzed using a lactate dehydrogenase release assay at 24 h after γ-irradiation. Radiation-induced cytotoxicity increased dose-dependent manner. Pre-treatments pro-apoptotic caspase inhibitors and anti-oxidative substances significantly blocked γ-irradiation-induced The results suggest that caspase-dependent γ-rays cultured may be caused by oxidative stress.
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