Ectopic expression of N-cadherin perturbs histogenesis in Xenopus embryos.
作者： M. Takeichi , T. Fujimori , S. Miyatani
DOI: 10.1242/DEV.110.1.97
关键词:
摘要: Xenopus embryos express N-cadherin in a pattern similar to that observed other species, and cells expressing can bind chicken vitro. To investigate the developmental role of this molecule, we injected mRNA encoding into one blastomere 2-cell-stage examined effect its expression on their development. The ectopic occurred various regions induced abnormal histogenesis, such as thickening, clumping or fusion cell layers. These results suggest precise quantitative qualitative regulation cadherins is essential embryonic morphogenesis.
biologists.org
biologists.com参考文章(10)
Kohei Hatta, Masatoshi Takeichi, Expression of N-cadherin adhesion molecules associated with early morphogenetic events in chick development Nature. ,vol. 320, pp. 447- 449 ,(1986) , 10.1038/320447A0
G Levi, K L Crossin, G M Edelman, Expression sequences and distribution of two primary cell adhesion molecules during embryonic development of Xenopus laevis. Journal of Cell Biology. ,vol. 105, pp. 2359- 2372 ,(1987) , 10.1083/JCB.105.5.2359
Sharon J. Busby, Ronald H. Reeder, Fate of amplified nucleoli in Xenopus laevis embryos Developmental Biology. ,vol. 91, pp. 458- 467 ,(1982) , 10.1016/0012-1606(82)90052-5
R.P. Harvey, D.A. Melton, Microinjection of synthetic Xhox-1A homeobox mRNA disrupts somite formation in developing Xenopus embryos Cell. ,vol. 53, pp. 687- 697 ,(1988) , 10.1016/0092-8674(88)90087-6
Mark A. Seeger, Laura Haffley, Thomas C. Kaufman, Characterization of amalgam: a member of the immunoglobulin superfamily from Drosophila. Cell. ,vol. 55, pp. 589- 600 ,(1988) , 10.1016/0092-8674(88)90217-6
Akira Nagafuchi, Yasuaki Shirayoshi, Kenji Okazaki, Kunio Yasuda, Masatoshi Takeichi, Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA Nature. ,vol. 329, pp. 341- 343 ,(1987) , 10.1038/329341A0
M Takeichi, Functional correlation between cell adhesive properties and some cell surface proteins. Journal of Cell Biology. ,vol. 75, pp. 464- 474 ,(1977) , 10.1083/JCB.75.2.464
M. Takeichi, The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. Development. ,vol. 102, pp. 639- 655 ,(1988) , 10.1242/DEV.102.4.639
M. Leptin, A. DiAntonio, M. Wilcox, The function of PS integrins in Drosophila wing morphogenesis. Development. ,vol. 107, pp. 891- 897 ,(1989) , 10.1242/DEV.107.4.891
P. D. Nieuwkoop, J. Faber, Normal Table of Xenopus Laevis (Daudin) Copeia. ,vol. 1958, pp. 65- ,(1958) , 10.2307/1439568