Dimeric Cinchona alkaloids

摘要: Nature is full of dimeric alkaloids various types from many plant families, some them with interesting biological properties. However, Cinchona were not isolated any species but products designed partial chemical synthesis. Although the bark amongst sources oldest efficient medicines, synthetic dimers found most use in field asymmetric Prominent examples include Sharpless dihydroxylation and aminohydroxylation ligands, phase transfer catalysts. In this article syntheses alkaloid oligomers are reviewed, their structure applications outlined. Various routes exploit reactivity at central 9-hydroxyl group, quinuclidine, quinoline rings, as well 3-vinyl group. This availability reactive sites, combination a plethora linker molecules, contributes to diversity obtained.