Click-Dimerized Cinchona Alkaloids
作者： Przemysław J. Boratyński , Rafał Kowalczyk
关键词: Michael reaction 、 Click chemistry 、 Linker 、 Chemistry 、 Cycloaddition 、 Stereochemistry 、 Cinchona Alkaloids 、 Cinchona
摘要: A series of Cinchona alkaloid-derived dimers were obtained in high yields copper-catalyzed 1,3-dipolar “click” cycloaddition using bis(TMS)butadiyne and other bivalent alkynes. The products with bitriazole linkers effective ligands for asymmetric Michael addition. It was shown that the presence such linker responsible chirality transfer.
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